熊去氧胆酸
熊去氧胆酸（英語：Ursodeoxycholic acid，也被称为3α,7β-二羟基-5β-胆烷-24-羧酸，3α,7β-dihydroxy-5β-cholan-24-oic acid，缩写 UDCA），是一种来自熊膽的胆汁酸[1]，为次级胆汁酸，由初级胆汁酸经由细菌代谢生成。
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| 臨床資料 | |
|---|---|
| 商品名 | Actigall |
| 其他名稱 | ursodeoxycholic acid, Actigall, Ursosan, Urso, Urso Forte |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a699047 |
| 核准狀況 | |
| 懷孕分級 |
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| 给药途径 | oral |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 识别信息 | |
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| CAS号 | 128-13-2  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
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| ChEBI | |
| ChEMBL | |
| PDB配體ID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.004.437 |
| 化学信息 | |
| 化学式 | C24H40O4 |
| 摩尔质量 | 392.56 g/mol |
| 3D模型（JSmol） | |
| 熔点 | 203 °C（397 °F） |
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歷史编辑
熊胆是熊去氧胆酸的天然来源。1955年，日本科学家成功化学合成了熊去氧胆酸[3]。1987年12月，艾尔建申請的熊去氧胆酸獲准在美國上市。[4]
参考文献编辑
- ^ 放過熊吧！可治療膽結石的熊膽早就能用化學合成. 食力 foodNEXT. [2021-12-08]. （原始内容存档于2021-12-08） （中文（臺灣））.
- ^ Teresa Brevini, Mailis Maes, Gwilym J. Webb, Binu V. John, Claudia D. Fuchs, Gustav Buescher, Lu Wang, Chelsea Griffiths, Marnie L. Brown, William E. Scott, Pehuén Pereyra-Gerber, William T. H. Gelson, Stephanie Brown, Scott Dillon, Daniele Muraro, Jo Sharp, Megan Neary, Helen Box, Lee Tatham, James Stewart, Paul Curley, Henry Pertinez, Sally Forrest, Petra Mlcochova, Sagar S. Varankar, Mahnaz Darvish-Damavandi, Victoria L. Mulcahy, Rhoda E. Kuc, Thomas L. Williams, James A. Heslop, Davide Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Thomas W. M. Crozier, Johannes Bargehr, Sanjay Sinha, Sara S. Upponi, Corrina Fear, Lisa Swift, Kourosh Saeb-Parsy, Susan E. Davies, Axel Wester, Hannes Hagström, Espen Melum, Darran Clements, Peter Humphreys, Jo Herriott, Edyta Kijak, Helen Cox, Chloe Bramwell, Anthony Valentijn, Christopher J. R. Illingworth, UK-PBC research consortium, Bassam Dahman, Dustin R. Bastaich, Raphaella D. Ferreira, Thomas Marjot, Eleanor Barnes, Andrew M. Moon, Alfred S. Barritt, Ravindra K. Gupta, Stephen Baker, Anthony P. Davenport, Gareth Corbett, Vassilis G. Gorgoulis, Simon J. A. Buczacki, Joo-Hyeon Lee, Nicholas J. Matheson, Michael Trauner, Andrew J. Fisher, Paul Gibbs, Andrew J. Butler, Christopher J. E. Watson, George F. Mells, Gordon Dougan, Andrew Owen, Ansgar W. Lohse, Ludovic Vallier, Fotios Sampaziotis. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022-12-05 [2022-12-07]. ISSN 0028-0836. doi:10.1038/s41586-022-05594-0. （原始内容存档于2023-06-26） （英语）.
- ^ Feng Y, Siu K, Wang N, Ng KM, Tsao SW, Nagamatsu T, Tong Y. Bear bile: dilemma of traditional medicinal use and animal protection. Journal of Ethnobiology and Ethnomedicine. 2009, 5 (1): 2. PMC 2630947
. PMID 19138420. doi:10.1186/1746-4269-5-2. - ^ Actigall: FDA-Approved Drugs. U.S. Food and Drug Administration (FDA). [29 April 2020]. （原始内容存档于2020-10-19）.
