吉爾波特症候群

吉爾波特症候群
同义词	Gilbert–Meulengracht syndrome
	胆红素
读音	/ʒiːlˈbɛərz/ zheel-BAYR ;
类型	bilirubin metabolic disorder[*]、疾病
分类和外部资源
醫學專科	肝臟病學、家庭醫學
ICD-11	5C58.01
ICD-10	E80.4
ICD-9-CM	277.4
OMIM	143500
DiseasesDB	5218
MedlinePlus	000301
eMedicine	med/870
MeSH	D005878
Orphanet	357
	[编辑此条目的维基数据]

吉爾波特症候群（英語：Gilbert's syndrome，簡稱GS）為一種常見的遺傳性肝臟疾病，盛行率約3-12%^[1]^[2]^[3]^[4]^[5]。

患者體内的非共軛性膽紅素會顯著提升，但沒有明顯併發症，患者可能會在運動後產生輕微黃疸。

造成此疾病的原因為患者的葡萄糖醛酸苷轉移酶（英语：glucuronyltransferase）功能不佳^[6]^[7]，使非共軛膽紅素無法轉化為較為水溶的共軛膽紅素。

知名病例编辑

拿破仑一世^[8]
阿瑟·科恩伯格，1959年諾貝爾生理醫學獎得主^[9]。
Nicky Wire（英语：Nicky Wire），狂躁街道传教者^[10]。
亞歷山大·多爾戈波洛夫，烏克蘭職業網球選手^[11]。

參考文獻编辑

^ ^1.0 ^1.1 Gilbert's syndrome. Mayo Clinic. July 2, 2015 [2017-05-26]. （原始内容存档于2017-11-08）.
^ Dugdale, David C. Gilbert's disease. MedlinePlus. U.S. National Library of Medicine. 2013-05-13 [10 February 2014]. （原始内容存档于2016-07-05）.
^ Gilbert Syndrome. American Liver Foundation. [2017-05-26]. （原始内容存档于2017-11-15）.
^ Gilbert's syndrome. NHS Choices. [2017-05-26]. （原始内容存档于2017-10-03）.
^ What is Gilbert syndrome?. Genetics Home Reference. February 2012 [2017-05-26]. （原始内容存档于2019-04-08）.
^ Bosma, PJ; Chowdhury, JR; Bakker, C; Gantla, S; de Boer, A; Oostra, BA; Lindhout, D; Tytgat, GN; Jansen, PL; Oude Elferink, RP. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.. The New England Journal of Medicine. 2 November 1995, 333 (18): 1171–5. PMID 7565971. doi:10.1056/nejm199511023331802.
^ Koiwai, O; Nishizawa, M; Hasada, K; Aono, S; Adachi, Y; Mamiya, N; Sato, H. Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase.. Human Molecular Genetics. July 1995, 4 (7): 1183–6. PMID 8528206. doi:10.1093/hmg/4.7.1183.
^ Foulk, WT; Butt, HR; Owen, CA Jr; Whitcomb, FF Jr; Mason, HL. Constitutional hepatic dysfunction (Gilbert's disease): its natural history and related syndromes. Medicine (Baltimore). 1959, 38 (1): 25–46. PMID 13632313.
^ Shmaefsky, Brian. 5. Biotechnology 101. Greenwood Publishing Group. 2006: 175 [2017-05-26]. ISBN 978-0-313-33528-0. （原始内容存档于2019-08-02）.
^ Wire preaches delights of three cliffs. South Wales Evening Post（英语：South Wales Evening Post）. 2007-04-27: 3.
^ David Cox. A Tennis Player Learns to Be Aggressive for Health’s Sake. New York Times (Monte Carlo). 19 April 2014 [2017-05-26]. （原始内容存档于2016-10-14）.

外部連結编辑

Datagenno - Gilbert's syndrome（页面存档备份，存于互联网档案馆）
GilbertsSyndrome.com — collection of information on Gilbert's Syndrome, including symptom survey
Children's Liver Disease Foundation（页面存档备份，存于互联网档案馆）
Gilbert's syndrome NIH訂定的罕见病。
Gilbert's Syndrome（页面存档备份，存于互联网档案馆） BMJ Best Practices monograph

[mayo-1] 1.0 ^1.1 Gilbert's syndrome. Mayo Clinic. July 2, 2015 [2017-05-26]. （原始内容存档于2017-11-08）.

[MedLine-2] Dugdale, David C. Gilbert's disease. MedlinePlus. U.S. National Library of Medicine. 2013-05-13 [10 February 2014]. （原始内容存档于2016-07-05）.

[3] Gilbert Syndrome. American Liver Foundation. [2017-05-26]. （原始内容存档于2017-11-15）.

[4] Gilbert's syndrome. NHS Choices. [2017-05-26]. （原始内容存档于2017-10-03）.

[5] What is Gilbert syndrome?. Genetics Home Reference. February 2012 [2017-05-26]. （原始内容存档于2019-04-08）.

[6] Bosma, PJ; Chowdhury, JR; Bakker, C; Gantla, S; de Boer, A; Oostra, BA; Lindhout, D; Tytgat, GN; Jansen, PL; Oude Elferink, RP. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.. The New England Journal of Medicine. 2 November 1995, 333 (18): 1171–5. PMID 7565971. doi:10.1056/nejm199511023331802.

[7] Koiwai, O; Nishizawa, M; Hasada, K; Aono, S; Adachi, Y; Mamiya, N; Sato, H. Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase.. Human Molecular Genetics. July 1995, 4 (7): 1183–6. PMID 8528206. doi:10.1093/hmg/4.7.1183.

[Foulk-8] Foulk, WT; Butt, HR; Owen, CA Jr; Whitcomb, FF Jr; Mason, HL. Constitutional hepatic dysfunction (Gilbert's disease): its natural history and related syndromes. Medicine (Baltimore). 1959, 38 (1): 25–46. PMID 13632313.

[Shmaefsky-9] Shmaefsky, Brian. 5. Biotechnology 101. Greenwood Publishing Group. 2006: 175 [2017-05-26]. ISBN 978-0-313-33528-0. （原始内容存档于2019-08-02）.

[swep-10] Wire preaches delights of three cliffs. South Wales Evening Post（英语：South Wales Evening Post）. 2007-04-27: 3.

[11] David Cox. A Tennis Player Learns to Be Aggressive for Health’s Sake. New York Times (Monte Carlo). 19 April 2014 [2017-05-26]. （原始内容存档于2016-10-14）.

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