HLA-C

Major histocompatibility complex, class I, C; 主要组织相容性抗原复合物，第一类，C
	Illustration of an HLA-C showing the HLA-B 'alpha' chain, ?2-Microglobulin, and the end of a peptide bound in the binding cleft.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	3BZF
标识
代号	HLA-C; D6S204; HLA-JY3; HLC-C; PSORS1
扩展标识	遗传学：142840 同源基因：133080 GeneCards: HLA-C Gene
基因本体论描述
分子功能	· MHC class I receptor activity;
细胞成分	· Golgi membrane; · extracellular region; · plasma membrane; · integral to plasma membrane; · ER to Golgi transport vesicle membrane; · phagocytic vesicle membrane; · early endosome membrane; · MHC class I protein complex; · integral to lumenal side of endoplasmic reticulum membrane;
生物过程	· antigen processing and presentation of peptide antigen via MHC class I; · antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; · antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; · immune response; · virus-host interaction; · cytokine-mediated signaling pathway; · antigen processing and presentation of exogenous peptide antigen via MHC class I; · innate immune response; · regulation of immune response; · interferon-gamma-mediated signaling pathway; · type I interferon-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
	查; 论; 编;

HLA-C是人類白細胞抗原（HLA）的一个基因座，位于6号染色体上。成熟的HLA-C蛋白会与β2微球蛋白组成异二聚体，作为一个受体锚定在细胞表面。

参考文献编辑

Geyer M, Fackler OT, Peterlin BM. Structure--function relationships in HIV-1 Nef.. EMBO Rep. 2001, 2 (7): 580–5. PMC 1083955  . PMID 11463741. doi:10.1093/embo-reports/kve141.
Greenway AL, Holloway G, McPhee DA; et al. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.. J. Biosci. 2004, 28 (3): 323–35. PMID 12734410. doi:10.1007/BF02970151.
Bénichou S, Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]. Med Sci (Paris). 2003, 19 (1): 100–6. PMID 12836198. doi:10.1051/medsci/2003191100.
Leavitt SA, SchOn A, Klein JC; et al. Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.. Curr. Protein Pept. Sci. 2004, 5 (1): 1–8. PMID 14965316. doi:10.2174/1389203043486955.
Tolstrup M, Ostergaard L, Laursen AL; et al. HIV/SIV escape from immune surveillance: focus on Nef.. Curr. HIV Res. 2004, 2 (2): 141–51. PMID 15078178. doi:10.2174/1570162043484924.
Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection.. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.
Anderson JL, Hope TJ. HIV accessory proteins and surviving the host cell.. Current HIV/AIDS reports. 2005, 1 (1): 47–53. PMID 16091223. doi:10.1007/s11904-004-0007-x.