脑源性神经营养因子
脑源性神经营养因子(brain-derived neurotrophic factor,BDNF,abrineurin[1])是人脑中的一种蛋白质,由脑源性神经营养因子基因生成。脑源性神经营养因子是神经营养因子中的一种,这种因子存在于人的神经系统中。
BDNF是大腦中含量最豐富的蛋白質,在腦部可以促進神經元 (神經細胞) 的生長,也促進大腦神經細胞突觸的成形。簡單來說,就是大腦非常需要的營養蛋白質。研究顯示,在大腦中掌管記憶的海馬迴中含有特別豐富的 BDNF ,對於突觸的生長以及長期記憶也非常重要。已經有許多國際研究顯示,缺乏 BDNF 將可能造成一些認知障礙,例如阿茲海默症,此為常見的退化性失智症之一。
另外,若長期處於壓力大或憂鬱的狀態,也可能會抑制大腦 BDNF 的分泌,影響記憶及認知功能,甚至於導致自律神經失調或海馬迴萎縮等更嚴重的問題。
註釋编辑
- ^ Girotra P, Behl T, Sehgal A, Singh S, Bungau S. Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer's Disease. J Mol Neurosci. 2022 Feb;72(2):173-186. doi: 10.1007/s12031-021-01824-8. Epub 2021 Aug 23. PMID 34424488.
延伸閱讀编辑
- Fawzi MH, Kira IA, Fawzi MM, Mohamed HE, Fawzi MM. Trauma profile in Egyptian adolescents with first-episode schizophrenia: relation to psychopathology and plasma brain-derived neurotrophic factor. J. Nerv. Ment. Dis. January 2013, 201 (1): 23–9. PMID 23274291. doi:10.1097/NMD.0b013e31827ab268.
- Vaynman S, Gomez-Pinilla F. Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J. Neurosci. Res. September 2006, 84 (4): 699–715. PMID 16862541. doi:10.1002/jnr.20979.
- van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U.S.A. November 1999, 96 (23): 13427–31. PMC 23964 . PMID 10557337.
- Gómez-Pinilla F, Ying Z, Roy RR, Molteni R, Edgerton VR. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. November 2002, 88 (5): 2187–95. PMID 12424260. doi:10.1152/jn.00152.2002.
- Meerwijk, Esther L., Judith M. Ford, and Sandra J. Weiss. Brain regions associated with psychological pain: implications for a neural network and its relationship to physical pain. Brain imaging and behavior. 2013, 7 (1): 1–14. PMID 12424260. doi:10.1007/s11682-012-9179-y.
外部連結编辑
- Cotman CW, Berchtold NC. BDNF and Alzheimer's Disease—What's the Connection?. Alzforum: Live Discussions. Alzheimer Research Forum. 2004-01-28 [2008-08-21]. (原始内容存档于2008-10-11).
- Patten-Hitt E. Brain-Derived Neurotrophic Factor (BDNF). Sciencexpress. The HDLighthouse, Huntingtons Disease: Information and Community. 2001-06-14 [2008-08-21]. (原始内容存档于2008-07-25).
- Highfield R. Brain scans 'could reveal mental strength'. Science. Telegraph.co.uk. 2007-10-18 [2008-08-21]. (原始内容存档于2008-05-31).
Low BDNF activity promotes resilience
Template:Nerve growth factor family
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