丙咪嗪
丙咪嗪是一种口服三环类抗抑郁药，主要用于治疗抑鬱。它还可以治疗焦慮和恐慌症。[5][6][7]
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| 臨床資料 | |
|---|---|
| 商品名 | Tofranil, Tofranil-PM, others |
| 其他名稱 | Melipramine; G-22355 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682389 |
| 核准狀況 | |
| 懷孕分級 | |
| 给药途径 | By mouth, intramuscular injection |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 藥物動力學數據 | |
| 生物利用度 | 94–96%[2] |
| 血漿蛋白結合率 | 86%[3] |
| 药物代谢 | Liver (CYP1A2, CYP2C19, CYP2D6)[3] |
| 代謝產物 | Desipramine[3] |
| 生物半衰期 | 20 hours[3] |
| 排泄途徑 | Kidney (80%), fecal (20%)[3] |
| 识别信息 | |
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| CAS号 | 50-49-7  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| PDB配體ID | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.039 |
| 化学信息 | |
| 化学式 | C19H24N2 |
| 摩尔质量 | 280.42 g·mol−1 |
| 3D模型（JSmol） | |
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丙咪嗪的常见副作用有口乾、昏睡、頭暈、低血壓、心跳过速、尿瀦留。丙咪嗪过量可能會导致死亡。
丙咪嗪于1951年被发现，并于1957年投入臨床使用。
参考文献编辑
- ^ Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020].
- ^ Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
- ^ 3.0 3.1 3.2 3.3 3.4 Product Information Tolerade (imipramine hydrochloride). TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. （原始内容存档于10 December 2019）.
- ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）.
- ^ Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
- ^ Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.
- ^ Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.